ABSTRACT
Objective To compare the clinical intravenous anesthesia effect of sufentanil and remifentanil respectively, in order to provide data support for future clinical practice. Methods 91 surgery patients from February 2013 to October 2013 were selected and randomly divided into 2 groups, the one is sufentanil group (group A), and the other is remifentanil group(group B). The change of hemodynamic indexes, catecholamine concentration and woke up time after surgery in two groups were monitored and compared. Results Compared with T 0, levels of SP, DP, HR in two groups were signiifcantly lower (P<0.05), at the moment of T 2, the levels of SP, DP, HR level got signiifcantly higher(P<0.05), even surpass T 0(P<0.05). And the range of the rise in group A was signiifcant than that in group B(P<0.05).Epinephrine and norepinephrine of group A in T 2 and T 6, were higher than T 0 (P<0.05). The spontaneous breathing recovery time was, (5.2±1.9)min, open eyes’time, (7.2±2.0) min, and conscious time was(14.6±2.3)min in group B, which were lower than that of group A(t=14.382, 14.934, 14.382, P<0.01).There were no adverse reactions in both groups. Conclusion Remifentanil has good anesthetic effect, postoperative patients wake up soon, self breathing early. The change of hemodynamic index and catecholamine index are stable and beneifcial to internal environment balance.
ABSTRACT
Objective To investigate the effects of stellate ganglion block(SGB) on the pulmonary artery endothelial nitric oxide synthase (eNOS) and mean pulmonary artery pressure ( MPAP) in rabbits with hypoxic pulmonary hypertension ( HPH) .Methods Twenty-four rabbits of both sexes weighing 2.5-3.0 kg were anesthetized with 1.5% sodium pentobarbital 30 mg? kg-1 . Spontaneous breathing was maintained. Left stellate ganglion was exposed aseptically. An epidural catheter was fixed with one end placed close to stellate ganglion and the other end outside the neck through a hole in the skin for administration of drugs. One week later the rabbits were randomly divided into 4 groups with 6 animals in each group: Ⅰ control group; Ⅱ SGB group; Ⅲ hypoxia group and Ⅳ SGB + hypoxia. In group Ⅲ and Ⅳ the animals were placed in a closed box filled with hypoxic air (O2 % = 10 ? 2% ) 8 h a day for 2 weeks. In group Ⅱ and Ⅳ 0.25% bupivacaine 0.5 ml was injected through the catheter 3 times a day for 3 days. In group Ⅰ and Ⅲ normal saline 0.5 ml was injected instead of bupivacaine. The effect of SGB was confirmed by ptosis and miosis. The content of eNOS in pulmonary artery was detected using immunohistocheistry technique. Pulmonary artery was cannulated after thoracotomy for determination of MPAP. Results There was no significant difference in MPAP between control and SGB groups. MPAP was significantly increased in hypoxia and hypoxia + SGB groups compared with control group(P